WORKSHOP

The Ubiquitin Workshop 2010

Date: August 23, 2010
Location: Four Seasons Hotel, Philadelphia, PA

WORKSHOP DETAILS

View the Pre-Conference Workshop Flyer Summary of Workshop

The workshop is designed to familiarize researchers and executives with state of the art technology and methods being used to decipher the complex ubiquitin signaling networks.  The workshop will cover the available tools and reagents currently used to understand ubiquitin mediated signaling.  In 2009 the workshop focused on HTS assays using surrogate substrates.  In 2010 the workshop will focus on tools aimed at uncovering the physiological function of ubiquitin conjugating and deconjugating enzymes.  These sessions will also include extensive discussion sessions to allow attendees to share their own experiences and ask advice on how to approach problems. Space is limited to ensure that all attendees have the opportunity to interact with experts in the ubiquitin field.

 
Pre-Conference Program:
 
Session 1: 
Session Chair: Dr. James E. Strickler
 
1:00pm     Welcoming Remarks
      Dr. Paul W. Sheppard
      ENZO Life Sciences(UK) LTD

1:10pm     Tools for Characterizing Polyubiquitin Linkages
      Dr. Donald S. Kirkpatrick
      Genentech, Inc.

1:50pm     Characterization of Proteasome Complexes
                   Using Proteomic Approaches
      Dr. Lan Huang
      University of California, Irvine School of Medicine
 
2:30pm     UbiScan: Quantifying Ubiquitination Sites in Cells and Tissues
                    Dr. Matthew Stokes
                    Cell Signaling Technology, Inc.

2:50pm     New approaches for determining the 
      activity of deubiquitinylating enzymes
      Dr. James E. Strickler
      LifeSensors, Inc.

3:30pm     Role of Ubiquitination and UBPY-dependent deubiquitination in the
                   endocytosis and lysosomal targeting of plasma membrane KCa3.1
      Dr. Corina M. Balut
      University of Pittsburgh, School of Medicine
 
3:50pm     Break
 
Session 2:
Session Chair: Dr. Paul W. Sheppard
 
4:20pm       E3 Ligases and the Challenges of 
        Drug Discovery: Lessons From the
        Mechanism of the Trim Ligase 
        Superfamily
        Dr. Arthur L. Haas
        LSU Health Sciences Center
        School of Medicine

5:00pm       An Emerging Therapeutic Target Class - Where to Start?
                     The Development of a High Throughput Homogeneous Assay
                      to Identify Inhibitors of Ubiquitin Ligases
        Dr. Paul Andrews
        Amgen, Inc.

5:30pm        A genome-wide screen for modulators 
        of cell death induced by the NEDD8-
        activating enzyme inhibitor MLN4924
                     Dr. Eric S. Lightcap
                     Millennium: The Takeda Oncology  Company

6:00pm     A Novel Cell-Based Drug Discovery Assay for Screening
                   Modulators of Protein Aggregation and Toxicity
                   Dr. Wayne Patton
                   ENZO Life Sciences
 
6:20pm    SUMO-binding proteins as effectors and regulators of SUMO modification
                   Dr. Catherine M. Guzzo
                  Johns Hopkins University, School of Medicine
 

7:00pm  Event Ends